Peer-reviewed veterinary case report
Urinary heat shock protein 72 detects acute kidney injury in dogs
By Bruchim, Yaron et al.·Published in Veterinary journal (London, England : 1997)·2017·Koret School of Veterinary Medicine·View original on PubMed →
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Original publication title: Urinary heat shock protein 72 as a biomarker of acute kidney injury in dogs.
- Species:
- dog
Plain-English summary
A group of dogs with acute kidney injury (AKI) had their urine tested for a specific protein to help diagnose the condition early. The study found that the level of this protein, called heat shock protein-72, was significantly higher in dogs with AKI compared to healthy dogs and those with urinary tract infections. This test showed a very high accuracy in identifying AKI, which could help veterinarians start treatment sooner. The findings suggest that measuring this protein in urine could be a valuable tool for diagnosing and predicting outcomes in dogs with kidney issues.
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Abstract
Early recognition of acute kidney injury (AKI) is important, as therapy is potentially more efficacious if instituted early in the course of disease. Urinary heat shock protein-72 to urinary creatinine ratio (uHSP72/uCr) was assessed as a diagnostic and prognostic marker in AKI in dogs. Fifty-three dogs were enrolled in five groups: healthy controls (n=11), urinary tract infection (n=10), chronic kidney disease (CKD; n=11), AKI (n=13), and acute decompensating CKD (n=8). Urinary heat shock protein-72 to urinary creatinine ratio was highest in the AKI group (P<0.001 when compared to the control and urinary tract infection groups, individually; P>0.05 compared to each of the other two groups). The area under the curve (AUC) for the receiver operator characteristic (ROC) analysis of uHSP72/uCr to predict AKI, compared to the control group, was 0.97. A cutoff value of 0.20ng/mg corresponded to sensitivity and specificity of 100% and 82%, respectively. Urinary heat shock protein-72 to urinary creatinine ratio was significantly lower in dogs categorized as survivors vs. non-survivors of AKI; ROC AUC, 0.91 (95% confidence intervals, 0.74-1.0). Urinary heat shock protein-72 to urinary creatinine ratio is a potentially useful diagnostic and prognostic biomarker of AKI in dogs.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/28720296/