Peer-reviewed veterinary case report
Urinary protein patterns in dogs with chronic kidney disease
By Navarro, Paula Fátima et al.·Published in Frontiers in veterinary science·2022·Department of Veterinary Medicine and Surgery, Spain·View original on PubMed →
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Original publication title: Urinary phoretograms performed by capillary electrophoresis in dogs with chronic disease with or withoutinfection.
- Species:
- dog
Plain-English summary
A group of dogs with chronic kidney disease (CKD) were tested using a new urine test called urinary capillary electrophoresis (UCE) to help detect kidney problems earlier. The study found that certain patterns in the urine samples could indicate kidney issues, even before traditional blood tests showed problems. This technique could be useful for diagnosing and monitoring dogs with kidney disease, whether or not they also had infections. Overall, UCE shows promise as a non-invasive way to assess kidney health in dogs.
People also search for: dog kidney disease symptoms · chronic kidney disease in dogs · urine test for dog kidney problems
Abstract
INTRODUCTION: The study of early markers to detect kidney malfunction has increased in recent years since serum markers, such as creatinine increase when there is a 75% loss of renal mass. Urinary capillary electrophoresis (UCE) is an available laboratory technique that provides an easily interpretable electrophoretic pattern. This pattern in our study has been divided into five fractions as it is done in serum: fraction 1 migrating in the albumin zone, fraction 2 in the alpha-globulins zone, fraction 3 in the alpha-globulins zone, fraction 4 in the beta-globulins zone, and fraction 5 in the gamma globulins zone. UCE can be useful in the early diagnosis of renal disease. MATERIAL AND METHODS: In this study, UCE was performed in dogs with azotemia and proteinuria due to chronic kidney disease (CKD) not related to() infection (G,= 11) and dogs with CKD related toinfection (G,= 17) and compared with reference intervals from healthy dogs (G,= 123), with the aim of comparing their phoretograms and assessing changes in the fractions of the phoretograms based on the health status of individuals. RESULTS: Fraction 2 was statistically augmented in dogs with CKD (G) when compared with the healthy population (G) and dogs infected by(G). Fraction 3 was statistically increased in dogs with CKD (G) and dogs infected by(G) compared with GFraction 4 was found to be statistically decreased in dogs with CKD (G) and dogs infected by(G) compared with GFraction 5 was statistically higher in dogs with(G) compared with Gand dogs with CKD (G). No statistical relationship was found between the protein to creatinine ratio and different fractions from the urinary phoretogram in the study population. No statistical relationship was found between serum and urine fractions in the study population. DISCUSSION: The results of the present study suggest that UCE is a promising non-invasive technique that might be used as a part of the diagnostic and follow-up in dogs with kidney disease due to different pathologies.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/36467666/