Peer-reviewed veterinary case report
Urine protein patterns in dogs with systemic inflammatory response
By Jung, Rankyung et al.·Published in Journal of veterinary internal medicine·2026·College of Veterinary Medicine, South Korea·View original on PubMed →
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Original publication title: Urine protein electrophoresis analysis in dogs with systemic inflammatory response syndrome.
- Species:
- dog
Plain-English summary
A group of dogs with systemic inflammatory response syndrome (SIRS) showed higher levels of certain proteins in their urine compared to dogs without SIRS. This study found that measuring the ratio of low molecular weight to high molecular weight proteins in urine can help veterinarians identify early kidney damage and predict outcomes for these dogs. The results suggest that this urine test could be a valuable tool for diagnosing and monitoring dogs with SIRS. If your dog is diagnosed with SIRS, discussing urine protein testing with your veterinarian may be beneficial.
People also search for: dog kidney damage symptoms · SIRS in dogs treatment · urine protein test for dogs
Abstract
BACKGROUND: Serum biomarkers can underestimate renal damage in dogs with systemic inflammatory response syndrome (SIRS). HYPOTHESIS/OBJECTIVES: To identify differences in proteinuria patterns between dogs with and without SIRS using sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) and evaluate its value as an early diagnostic and prognostic indicator. ANIMALS: Client-owned, proteinuric dogs with (n = 10) and without (n = 21) SIRS. METHODS: In this retrospective study, urine electropherograms from SDS-PAGE were used to identify and quantify low molecular weight (LMW) and high molecular weight (HMW) protein bands. The LMW/HMW ratio was calculated for each dog and analyzed for correlations with the acute patient physiologic and laboratory evaluation (APPLE) full (APPLEfull) and fast (APPLEfast) scores and death within 2, 4, and 8 weeks. RESULTS: The LMW/HMW ratio and the proportion of proteins with molecular weights of 20-30 kDa were significantly higher in the SIRS than in the non-SIRS group (P < .001 and P = .018). The LMW/HMW ratio correlated with inflammatory (C-reactive protein, globulin, white blood cell, and band neutrophil counts) and renal markers (blood urea nitrogen and symmetric dimethylarginine; rho = 0.381-0.786, all P < .05). The LMW/HMW ratio showed a high predictive value for death within 2 (area under the curve [AUC] = 0.844, 95%CI, 0.597-1.091), 4 (AUC = 0.867, 95%CI, 0.682-1.041), and 8 weeks (AUC = 0.944, 95%CI, 0.802-1.087). CONCLUSIONS AND CLINICAL IMPORTANCE: An increased LMW/HMW ratio, reflecting elevated LMW proteinuria, can be a reliable diagnostic and prognostic indicator for early renal damage in dogs with SIRS.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/42132357/