Peer-reviewed veterinary case report
Cyclosporine treatment for brain inflammation in three dogs
By Adamo, Filippo P & O'Brien, Robert T·Published in Journal of the American Veterinary Medical Association·2004·Department of Medical Sciences, United States·View original on PubMed →
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Original publication title: Use of cyclosporine to treat granulomatous meningoencephalitis in three dogs.
- Species:
- dog
Plain-English summary
Three dogs were diagnosed with granulomatous meningoencephalitis, a serious brain condition, and were treated with cyclosporine, a medication that helps reduce inflammation. In two of the dogs, cyclosporine replaced steroids, while one dog received it as the only treatment. After a year, the two dogs with localized brain issues showed no signs of the disease, but the dog with the more widespread form only improved slightly and was euthanized three weeks later. Cyclosporine was given at a dose of 6 mg/kg every 12 hours, but some side effects included temporary low white blood cell counts and changes in their fur.
People also search for: dog brain disease treatment · granulomatous meningoencephalitis in dogs · cyclosporine side effects in dogs
Abstract
Use of cyclosporine to treat granulomatous meningoencephalitis in three dogs Three dogs with a presumptive diagnosis of granulomatous meningoencephalitis were treated with orally administered cyclosporine. In 2 dogs, cyclosporine administration replaced initial corticosteroid administration, and in 1 dog, cyclosporine was the only treatment used. One dog had the focal form of the disease in the brainstem, 1 dog had the focal form in the forebrain associated with a concurrent ocular form, and 1 dog had the disseminated form of disease. At 12-month follow-up, the 2 dogs with the focal form of the disease had no clinical signs. The dog with the disseminated form improved only partially, and euthanasia was performed 3 weeks after initial evaluation. Cyclosporine was considered effective at an initial dosage of 6 mg/kg (2.7 mg/lb) every 12 hours. Adverse effects associated with cyclosporine administration included transient lymphopenia, excessive shedding, and focal symmetric hair discoloration.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/15521442/