Peer-reviewed veterinary case report
Domperidone treatment reduces symptoms in dogs with visceral
By Gómez-Ochoa, P et al.·Published in Veterinary journal (London, England : 1997)·2009·Department of Animal Pathology, Spain·View original on PubMed →
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Original publication title: Use of domperidone in the treatment of canine visceral leishmaniasis: a clinical trial.
- Species:
- dog
Plain-English summary
A group of dogs with leishmaniasis, a disease caused by a parasite, were treated with a medication called domperidone for one month to see if it could help reduce their symptoms. After treatment, many dogs showed improvement: 74% with mild symptoms had lower antibody levels, and 86% of those with more severe signs improved as well. Additionally, some dogs even became seronegative, meaning they no longer tested positive for the disease. Overall, domperidone helped improve the dogs' health and immune response over the course of the study.
People also search for: dog leishmaniasis treatment · domperidone for dogs · symptoms of leishmaniasis in dogs
Abstract
The aim of this study was to evaluate the effects of domperidone, a dopamine D2 receptor antagonist, in dogs naturally infected by Leishmania infantum. Ninety-eight dogs were treated with single-agent domperidone at 1mg/kg twice a day orally for 1 month. Clinical, serological, biochemical and immunological examinations were conducted for the following 12 months. Domperidone was effective in controlling and reducing clinical signs and antibody titre. Significant decreases in reciprocal serum antibodies were seen in 74.3% of the dogs with mild clinical signs and 40% of the dogs became seronegative. In dogs with several clinical signs and high antibody titres, clinical improvement occurred in 86% of animals and the reciprocal serum antibody titres decreased in 38% of these dogs. A significant increase was noted in the immune cellular status, as measured by the leishmanin skin test and a lymphocyte proliferation assay.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/18023375/