Peer-reviewed veterinary case report
Dog with estrogen-caused bone marrow failure treated successfully
By Hall, E J·Published in Journal of the American Veterinary Medical Association·1992·Veterinary Hospital, United States·View original on PubMed →
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Original publication title: Use of lithium for treatment of estrogen-induced bone marrow hypoplasia in a dog.
- Species:
- dog
Plain-English summary
A 6-year-old Old English Sheepdog was diagnosed with low blood cell counts due to bone marrow issues caused by hormone treatments. The veterinarian decided to try lithium carbonate as a treatment. After six weeks of this medication, the dog's bone marrow started to recover, which is a positive outcome given the serious nature of the condition. Fortunately, there were no noticeable side effects from the lithium treatment.
People also search for: dog low blood cell count treatment · Old English Sheepdog bone marrow issues · lithium for dog estrogen toxicity
Abstract
Marrow hypoplasia and consequent pancytopenia caused by simultaneous administration of estradiol cyclopentylpropionate and diethylstilbestrol were diagnosed in a 6-year-old Old English Sheep-dog. The dog was treated with lithium carbonate (11 mg/kg of body weight, PO, q 12 h) for 6 weeks. Despite the generally grave prognosis associated with estrogen toxicosis, lithium treatment was apparently successful in inducing regeneration of the bone marrow. Side effects of lithium treatment were not noticed.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/1568928/