Peer-reviewed veterinary case report
Dog with epitheliotropic lymphoma treated with human interferon
By Tzannes, Sophia et al.·Published in Journal of the American Animal Hospital Association·2008·Department of Clinical Veterinary Science, United Kingdom·View original on PubMed →
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Original publication title: Use of recombinant human interferon alpha-2a in the management of a dog with epitheliotropic lymphoma.
- Species:
- dog
Plain-English summary
An 8-year-old mixed-breed dog was diagnosed with a type of skin cancer called epitheliotropic lymphoma and initially treated with chemotherapy drugs, which only worked for a short time before the cancer progressed. After about seven weeks, the dog was given a treatment called recombinant human interferon alpha-2a, which quickly improved the dog's condition and kept the cancer at bay for 10 weeks. Unfortunately, the cancer returned after 17 weeks and did not respond to further chemotherapy. The dog then received localized radiation therapy for mouth lesions and higher doses of interferon, which helped maintain stable disease for another 12 weeks.
People also search for: dog lymphoma treatment · interferon for dogs · mixed-breed dog cancer care
Abstract
An 8-year-old, mixed-breed dog with preputial epitheliotropic lymphoma was initially treated with cyclophosphamide, vincristine, and prednisolone. A short-term partial response was followed by disease progression after 4 weeks. Recombinant human interferon alpha-2a was administered starting at week 7. The interferon therapy resulted in rapid resolution of clinical signs and a 10-week disease-free interval. The lymphoma recurred at 17 weeks and did not respond to rescue chemotherapy. Additional oral lesions were treated with localized radiotherapy followed by increased dosages of interferon. This additional interferon treatment resulted in another 12 weeks of stable disease.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/18762565/