Peer-reviewed veterinary case report
Carboplatin with amputation for bone cancer in dogs survival
By Phillips, Brenda et al.·Published in Journal of the American Animal Hospital Association·2009·Veterinary Specialty Hospital of San Diego, United States·View original on PubMed →
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Original publication title: Use of single-agent carboplatin as adjuvant or neoadjuvant therapy in conjunction with amputation for appendicular osteosarcoma in dogs.
- Species:
- dog
Plain-English summary
A group of dogs with appendicular osteosarcoma (a type of bone cancer) underwent amputation followed by treatment with carboplatin, a chemotherapy drug. The study found that the average time before the cancer returned was about 256 days, and the overall survival time was around 307 days. Dogs treated with carboplatin after amputation had better survival rates compared to those who only had the amputation. This suggests that carboplatin can be an effective treatment option for dogs with this type of cancer.
People also search for: dog bone cancer treatment · appendicular osteosarcoma in dogs · carboplatin for dogs cancer · dog amputation recovery time
Abstract
Survival following amputation and administration of single-agent carboplatin for treatment of appendicular osteosarcoma (OSA) in dogs was retrospectively examined. Records of 155 dogs with appendicular OSA treated with amputation and single-agent carboplatin were included from 14 centers. Any carboplatin dosage, number of doses, and protocol schedule were eligible for inclusion. The median disease-free interval (DFI) was 256 days. The median overall survival time was 307 days. Similar prognostic survival factors were identified in this study as reported in prior studies of canine appendicular OSA. Median DFI and survival were comparable to those reported in the original Bergman et al publication. Carboplatin treatment improves the survival probability in dogs with appendicular OSA compared to amputation alone and remains an acceptable alternative to adjuvant treatment with cisplatin.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/19122062/