Peer-reviewed veterinary case report
Sodium nitroprusside did not lower blood pressure during dog PDA
By Humm, K R et al.·Published in Veterinary journal (London, England : 1997)·2007·Small Animal Hospital, United Kingdom·View original on PubMed →
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Original publication title: Use of sodium nitroprusside in the anaesthetic protocol of a patent ductus arteriosus ligation in a dog.
- Species:
- dog
Plain-English summary
A young dog with a heart condition called patent ductus arteriosus (PDA) underwent surgery to correct the issue. The veterinary team used a medication called sodium nitroprusside to help lower blood pressure during the procedure, which is intended to make surgery safer. However, the medication did not lower the dog's blood pressure as expected, meaning it didn't provide the intended benefits. The veterinarians suggested that other medications might be better options for safely lowering blood pressure in similar cases in the future.
People also search for: dog patent ductus arteriosus treatment · sodium nitroprusside for dogs · dog heart surgery recovery
Abstract
Patent ductus arteriosus (PDA) is one of the most common congenital cardiac abnormalities in the dog. Sodium nitroprusside has been proposed as an infusion during PDA ligation as the resultant nitric oxide production causes hypotension thereby facilitating surgical dissection and decreasing the risk of haemorrhage. This case report details how the method described did not decrease blood pressure and therefore had no beneficial effects. It is speculated that the lack of response may have been due to tachyphylaxis. Other drugs may be preferred to induce deliberate hypotension in the dog.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/16242365/