Peer-reviewed veterinary case report
Uveodermatologic lymphoma in young Portuguese water dogs
By Escanilla, Natàlia et al.·Published in Veterinary ophthalmology·2012·Hospital Clí, Spain·View original on PubMed →
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Original publication title: Uveodermatologic lymphoma in two young related Portuguese water dogs.
- Species:
- dog
Plain-English summary
A 1-year-old female Portuguese water dog was brought to the vet because she was squinting and had swelling around her right eye, along with skin bumps. Tests showed she had a type of eye problem called anterior exudative uveitis and a form of lymphoma, which is a type of cancer affecting the immune system. Interestingly, her brother, who lived far away, had similar symptoms and was also diagnosed with lymphoma. The vets believe that genetics may have contributed to both dogs developing this condition at such a young age.
People also search for: Portuguese water dog eye problems · dog skin bumps and eye squinting · lymphoma in young dogs
Abstract
PURPOSE: Canine lymphoma (CL) is one of the most common forms of spontaneous canine neoplasia. Improved understanding of the genetic and environmental factors associated with CL may provide benefits for the study of non-Hodgkin's and Hodgkin's lymphoma in humans. Uveodermatologic lymphoma is reported in a single household of Portuguese water dog, and the etiology is discussed. METHODS: A 1-year-old female intact Portuguese water dog was referred to the Ophthalmology Service of the Veterinary Teaching Hospital of the Autonomous University of Barcelona because of acute blepharospasm of the right eye in association with a multinodular dermatosis. Physical and ophthalmological examination and a complete diagnostic work-up, including skin and ocular histopathology and immunohistochemistry, were performed. Three months prior, in Galicia (Spain), 1200 km away from Barcelona, a male dog of the same litter showed very similar oculodermatological clinical signs and skin histopathology, and immunohistochemistry were obtained. RESULTS: The clinical diagnoses were anterior exudative uveitis, iridal masses, and secondary glaucoma. Histopathology and immunohistochemistry revealed a nonepitheliotropic lymphoma rich in B cell in dog 1 and rich in T cell in dog 2. CONCLUSION: It is proposed that an underlying genetic predisposition could have played a role in the development of lymphoma in these two young related dogs.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/22239173/