Peer-reviewed veterinary case report
Vaccination with Trypanosoma rangeli lowers infectiousness of dogs
By Basso, Beatriz et al.·Published in Vaccine·2007·Facultad de Ciencias Mé·View original on PubMed →
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Original publication title: Vaccination with Trypanosoma rangeli reduces the infectiousness of dogs experimentally infected with Trypanosoma cruzi.
- Species:
- dog
Plain-English summary
A group of mongrel dogs received a vaccine to help protect them from Trypanosoma cruzi, the parasite that causes Chagas disease. After getting three shots of the vaccine, these dogs showed fewer parasites in their blood compared to unvaccinated dogs. When bugs that spread the disease fed on the vaccinated dogs, they were less likely to become infected themselves. This suggests that vaccinating dogs could help lower the risk of spreading the disease to humans.
People also search for: dog vaccine Trypanosoma cruzi · Chagas disease in dogs · how to protect dogs from parasites
Abstract
The goal of this work was to test the efficacy of the vaccination with Trypanosoma rangeli in dogs. Mongrel dogs received three subcutaneous injections of fixed T. rangeli epimastigotes at 6-week intervals. Such immunisation induced antibodies against Trypanosoma cruzi. While both control and immunised dogs developed detectable parasitemia, this was lower and shorter in vaccinated animals. Interestingly, feeding of Triatoma infestans nymphs on vaccinated and chronically infected dogs led to a sharp reduction in the rate of bug infection. These results suggest that it might be possible to reduce the vectorial parasitemia through vaccination of dogs. As dogs are known to play a major role in the domestic cycle of T. cruzi, this might represent a strategy to reduce parasite transmission to humans.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/17349724/