Peer-reviewed veterinary case report
Dog develops abscess from cancer vaccine strain Listeria monocytogenes
By Margaret L. Musser et al.·Published in BMC Veterinary Research·2019·View original on Semantic Scholar →
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Original publication title: Vaccine strain Listeria monocytogenes abscess in a dog: a case report
- Species:
- dog
Plain-English summary
A dog with osteosarcoma (a type of bone cancer) developed a lump after receiving a vaccine designed to help treat his cancer. The lump was found to be an abscess caused by the vaccine strain of Listeria monocytogenes, which is usually safe but can cause issues in rare cases. The vet surgically removed the abscess and the affected ribs, and the dog continued treatment with chemotherapy. Remarkably, over a year later, the dog was still alive and showed no signs of cancer returning.
People also search for: dog cancer vaccine side effects · Listeria abscess in dogs · osteosarcoma treatment for dogs
Abstract
BackgroundListeria monocytogenes is a promising therapeutic vaccine vector for cancer immunotherapy. Although highly attenuated, three cases of systemic listeriosis have been reported in people following treatment with Listeria-based therapeutic vaccines. This complication has thus far not been reported in canine patients.Case presentationA dog previously diagnosed with osteoblastic osteosarcoma was presented for care following administration of three doses of the Canine Osteosarcoma Vaccine-Live Listeria Vector. On routine staging chest radiographs, mild sternal lymphadenopathy and a right caudoventral thoracic mass effect were noted. Further evaluation of the mass effect with computed tomography and ultrasound revealed a cavitated mass associated with the 7th right rib. Aspirates of the mass cultured positive for Listeria monocytogenes. The mass and associated ribs were surgically removed. Histopathology was consistent with metastatic osteoblastic osteosarcoma. Treatment was continued with doxorubicin chemotherapy and at the time of publication, the dog was alive over 1 year following diagnosis with no evidence of further disease progression. Genotyping of the abscess-derived L. monocytogenes was consistent with the vaccine strain.ConclusionsThis case represents the first veterinary case to describe development of a Listeria abscess following administration of a Listeria-based therapeutic vaccine.
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Search related cases →Original publication on Semantic Scholar: https://www.semanticscholar.org/paper/31864375