Peer-reviewed veterinary case report
Virulence and antifungal therapy of murine disseminated infection by Rhodotorula mucilaginosa.
- Journal:
- Diagnostic microbiology and infectious disease
- Year:
- 2017
- Authors:
- Thomson, Pamela et al.
- Affiliation:
- Unitat de Microbiologia · Spain
- Species:
- rodent
Abstract
Rhodotorula infections have emerged in recent years causing mainly fungemia associated to high mortality. We have evaluated the in vitro activity of nine antifungal drugs against four clinical strains of Rhodotorula mucilaginosa, being amphotericin B, voriconazole and posaconazole the most active compounds. The experimental virulence of this fungus and the efficacy of the three mentioned drugs were evaluated in disseminated infections in neutropenic mice. Infection resulted in a high fungal load in all the organs studied without evident particular tropism. All treated animals showed reduced burden respect to the control in a strain dependent manner being voriconazole slightly superior to posaconazole and amphotericin B.
Find similar cases for your pet
PetCaseFinder finds other peer-reviewed reports of pets with the same symptoms, plus a plain-English summary of what was tried across them.
Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/28669678/