Peer-reviewed veterinary case report
Trafermin helped close oronasal fistulas in dogs without tooth removal
By Watanabe, Kazuhiro et al.·Published in The Journal of veterinary medical science·2022·Joint Department of Veterinary Medicine, Japan·View original on PubMed →
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Original publication title: Visual and histological evaluation of the effects of trafermin in a dog oronasal fistula model.
- Species:
- dog
Plain-English summary
Four dogs with oronasal fistulas, which are openings between the mouth and nose, were treated with trafermin to see if it could help heal the tissue without needing to extract a tooth. After applying trafermin to one side of the fistula and leaving the other side untreated as a control, the dogs showed significant healing. By the eighth week, the fistulas treated with trafermin were completely closed, while the untreated sides did not show the same improvement. This suggests that trafermin could be a useful option for treating oronasal fistulas in dogs without losing a tooth.
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Abstract
The standard procedure to treat oronasal fistula in dogs requires tooth extraction to close the fistula; hence, the subject would lose its tooth. In this study, trafermin was applied to four dog models with oronasal fistula to investigate the periodontal tissue regenerative effects of trafermin in the treatment without tooth extraction. A fistula was created along the palatal side of each upper canine tooth. One of the fistulae was filled with trafermin, whereas that on the contralateral side was left unfilled as a control. The results showed a significant decrease in the non-calcified periodontal tissue volume on the trafermin side after the fourth week. In addition, oronasal fistula closure was visually and histologically confirmed at the eighth week on the trafermin side of all four models.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/34803085/