Peer-reviewed veterinary case report
VV116 shows strong effect against feline infectious peritonitis
By Wang, Huilong et al.·Published in Veterinary microbiology·2026·Shanghai Institute of Materia Medica, China·View original on PubMed →
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Original publication title: VV116 exerts potent efficacy against feline infectious peritonitis.
- Species:
- cat
Plain-English summary
A group of cats with feline infectious peritonitis (FIP), a serious viral disease, were treated with a new antiviral medication called VV116. This treatment significantly improved their health, with 75% of the cats surviving and showing reduced levels of the virus in their bodies. Additionally, the cats displayed noticeable improvements in their overall condition. These results suggest that VV116 could be a promising option for treating FIP in cats, and further studies are needed to confirm its effectiveness in veterinary practice.
People also search for: cat FIP treatment · feline infectious peritonitis antiviral · VV116 for cats
Abstract
Feline infectious peritonitis (FIP) is a fatal disease in cats caused by feline infectious peritonitis virus (FIPV) with no officially approved antiviral therapy. In this study, we evaluated the anti-FIPV potential of VV116 and found that it potently inhibited viral replication in CRFK cells (EC= 1.57 μM). In experimental FIPV-infected cats, VV116 significantly reversed clinicopathological abnormalities, improved survival to 75%, and reduced viral loads in most organs to levels below or at the limit of detection, achieving a greater reduction compared to GS‑441524. Marked histopathological improvement was also observed in both treated groups. Together, these findings support VV116 as a promising oral candidate for the treatment of FIP and warrant further evaluation in veterinary clinical settings.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/42019317/