Peer-reviewed veterinary case report
Dog with Waldenström's macroglobulinemia causing bleeding problems
By Jaillardon, Laetitia & Fournel-Fleury, Corinne·Published in Veterinary clinical pathology·2011·Department of Biology and Pathology, France·View original on PubMed →
PetCaseFinder translated the abstract of this peer-reviewed paper into plain English so pet owners can read it. We do not publish original research — every detail traces back to the citation above. How we work →
Original publication title: Waldenström's macroglobulinemia in a dog with a bleeding diathesis.
- Species:
- dog
Plain-English summary
An 11-year-old female spayed Whippet was brought to the vet after experiencing chronic bleeding, skin lumps that looked like bruises, and bloody diarrhea for three months. Tests showed low white blood cell counts and high protein levels, along with issues related to blood clotting. The diagnosis was Waldenström's macroglobulinemia, a type of blood cancer that can cause bleeding problems. The dog was treated with prednisone and chlorambucil, and she responded well to the treatment, showing improvement in her condition.
People also search for: Whippet dog bleeding problems · Waldenström's macroglobulinemia treatment · dog with skin lumps and diarrhea · prednisone for dog cancer · dog blood cancer symptoms
Abstract
An 11-year-old female spayed Whippet dog was referred to the Veterinary Hospital of the National Veterinary School of Lyon with a 3-month history of chronic bleeding, cutaneous masses suggestive of hematomas, and hemorrhagic diarrhea. Laboratory abnormalities included leukopenia with neutropenia and lymphopenia, rouleaux formation, marked hyperproteinemia with hyperglobulinemia and normoalbuminemia, hypercalcemia, markedly increased serum urea concentration, mildly increased creatinine concentration, and proteinuria. Hemostatic screening tests showed marked prolongation of thrombin time, increased concentrations of fibrin(ogen) degradation products and D-dimers, and slightly prolonged activated partial thromboplastin time. Serum and urine protein electrophoresis revealed a monoclonal peak identified as IgM by immunoelectrophoresis and an M-spike, respectively. Cytologic evaluation of bone marrow revealed a hypocellular sample with lymphoplasmacytic cells comprising approximately 50% of all nucleated cells. These findings were consistent with a diagnosis of Waldenström's macroglobulinemia with secondary bleeding diathesis. Treatment with prednisone and chlorambucil was initiated, and the dog had a good response.
Find similar cases for your pet
PetCaseFinder finds other peer-reviewed reports of pets with the same symptoms, plus a plain-English summary of what was tried across them.
Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/21827519/