Peer-reviewed veterinary case report
Canine bone cancer treatment options and outcomes review
By Szewczyk, M et al.·Published in Veterinary research communications·2015·Department of Small Animal Diseases with Clinic·View original on PubMed →
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Original publication title: What do we know about canine osteosarcoma treatment? Review.
- Species:
- dog
Plain-English summary
A dog with osteosarcoma (a type of bone cancer) faces a tough battle, as this cancer often spreads to the lungs. Treatment options include limb amputation or limb-sparing surgery, both of which have their pros and cons. Chemotherapy drugs like cisplatin, carboplatin, and doxorubicin can help prolong life, especially when used in combination. New approaches, such as nanotechnology, are being explored to improve treatment effectiveness and reduce side effects. While some dogs respond well to these treatments, the overall prognosis can still be challenging due to the aggressive nature of the disease.
People also search for: dog osteosarcoma treatment options · canine bone cancer prognosis · chemotherapy for dogs with cancer
Abstract
Osteosarcoma (OSA) is the most common type of bone tumors in dogs, which has high metastasis ability. 80 % of dogs with OSA die due to lung metastasis. As a result its treatment is a challenge for veterinary practitioners. The authors discuss the etiology, pathogenesis and the possible risk factors of OSA. The article focuses on literature review and the study of recent advances in OSA treatment. The authors describe therapies which have significantly prolonged the lives of dogs, as well as those that have proven to be ineffective. Advantages and disadvantages of limb amputation and limb-sparing surgery have been described. Authors present also the results of both single agent's therapies with the most commonly used drugs as cisplatin, carboplatin and doxorubicin and compare them to the results obtained using combined chemotherapy. The use of nanotechnology as a new approach in OSA treatment in order to avoid multidrug resistance and reduce negative side effects of cytostatic drugs is presented. The main reasons of the therapies failure are also provided in this article.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/25422073/