Peer-reviewed veterinary case report
World Association for the Advancement of Veterinary Parasitology (W.A.A.V.P.) guidelines for evaluating the efficacy of equine anthelmintics.
- Journal:
- Veterinary parasitology
- Year:
- 1988
- Authors:
- Duncan, J L et al.
- Affiliation:
- Department of Veterinary Parasitology · United Kingdom
- Species:
- horse
Plain-English summary
These guidelines are meant to help researchers design and carry out studies that test how well medications work against internal parasites in horses. While the focus is on anthelmintics (drugs that kill worms), the guidelines also cover treatments for larvae of horse bot flies, which are not worms but can still cause issues in a horse's stomach. They provide detailed advice on various aspects of the studies, including how to choose the right horses, their living conditions, feeding, dosing, and how to keep accurate records. The goal is to ensure that both researchers and regulatory bodies can evaluate these medications using consistent methods while minimizing the number of horses involved in the studies. Overall, these guidelines aim to improve the assessment of parasite treatments in horses.
Abstract
These guidelines have been designed to assist in the planning, operation and interpretation of studies which would serve to assess the efficacy of drugs against internal parasites of horses. Although the term anthelmintic is used in the title and text, these guidelines include studies on drug efficacy against larvae of horse bot flies, Gasterophilus spp, which are non-helminth parasites commonly occurring in the stomach of horses. The advantages, disadvantages and application of critical and controlled tests are presented. Information is also provided on selection of animals, housing, feed, dose titration, confirmatory and clinical trials, record keeping and necropsy procedures. These guidelines should assist both investigators and registration authorities in the evaluation of compounds using comparable and standard procedures with the minimum number of animals.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/3062882/