Peer-reviewed veterinary case report
Younger dogs of certain breeds risk rare reaction to injectable
By Saito, Emi K et al.·Published in Journal of the American Veterinary Medical Association·2023·1Banfield Pet Hospital, Canada·View original on PubMed →
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Original publication title: Younger dogs of specific breeds are more likely to experience a rare adverse event after administration of extended-release injectable moxidectin heartworm preventive.
- Species:
- dog
Plain-English summary
A study found that younger dogs of certain breeds are more likely to have a rare negative reaction after receiving an injectable heartworm preventive called moxidectin. Out of nearly 700,000 dogs treated over five years, about 14 out of every 10,000 doses resulted in an adverse event within three days. The breeds most affected were not specified, but the findings suggest that pet owners should be aware of these risks when choosing heartworm prevention for younger dogs. If your dog is in a high-risk group, discuss alternative heartworm prevention options with your veterinarian.
People also search for: heartworm prevention side effects · moxidectin reaction in dogs · young dog heartworm treatment risks
Abstract
OBJECTIVE: To estimate the incidence of and identify patient risk factors for an acute adverse event in dogs after administration of a sustained-release injectable heartworm preventive product. ANIMALS: Canine patients that received the injectable heartworm preventive product during routine preventive care visits. METHODS: Retrospective analysis of electronic medical records of canine visits within a large network of primary care veterinary clinics in which the product was administered from January 1, 2016, through December 31, 2020. Visits during which vaccination(s) were also administered were excluded from analysis. Identification of acute adverse events was based on diagnostic entries and other clinical presentations suggestive of an adverse event within 3 days of product administration. Data were analyzed using mixed-effects logistic regression. RESULTS: In the 5-year study period, 1,399,289 visits with 694,030 dogs led to an incidence estimate of approximately 14.3 events/10,000 doses. Regression analysis found younger dogs and 7 breeds (relative to mixed-breed dogs) to have statistically significant greater odds of an event. CLINICAL RELEVANCE: Understanding of incidence and patient risk factors provides veterinary professionals and dog owners more information when deciding on heartworm preventive options for their dog when considering risk for adverse event in dogs of certain ages or breeds.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/37380165/