Peer-reviewed veterinary case report
Dog with foreleg bone cancer treated with zoledronic acid infusion
By Spugnini, E P et al.·Published in The Journal of small animal practice·2009·S.A.F.U. Department (Stabilimento Allevatore, Italy·View original on PubMed →
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Original publication title: Zoledronic acid for the treatment of appendicular osteosarcoma in a dog.
- Species:
- dog
Plain-English summary
A 10-year-old male Corso dog was brought in for lameness and a large mass on his right foreleg. The vet diagnosed him with appendicular osteosarcoma, a type of bone cancer, but found no signs of it spreading. The owners chose to treat him with zoledronic acid, which is an antiresorptive therapy, given every 28 days. This treatment helped stabilize the tumor for 16 months and significantly improved the dog's lameness. Unfortunately, the dog later developed a rapidly growing mass in a lymph node, leading to euthanasia.
People also search for: dog lameness treatment · Corso dog osteosarcoma · zoledronic acid for dog cancer
Abstract
A 10-year-old male intact Corso dog was referred for lameness and for a large neoplasm affecting the right foreleg. Physical examination of the patient revealed a 5 x 5 x 3 cm mass in the distal right foreleg. Histopathology was consistent with a diagnosis of appendicular osteosarcoma. The staging process found no evidence of metastasis. Because of the large size of the patient, the owners elected to treat their dog with antiresorptive therapy. The patient was treated with an infusion of zoledronic acid every 28 days. The tumour remained stable for 16 months and the lameness of the dog greatly improved. At that time, the patient returned for evaluation of a large rapidly growing prescapular mass. Biopsy confirmed lymph node metastasis and the dog was euthanased. Zoledronic acid showed remarkable palliation in our patient and possibly anti-tumour action and warrants further investigation.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/18793253/