Peer-reviewed veterinary case report
4-Aryl-5-cyano-2-aminopyrimidines as VEGF-R2 inhibitors: synthesis and biological evaluation.
- Journal:
- Bioorganic & medicinal chemistry letters
- Year:
- 2007
- Authors:
- Hughes, Terry V et al.
- Affiliation:
- Johnson & Johnson Pharmaceutical Research and Development · United States
Abstract
A novel series of 4-aryl-5-cyano-2-aminopyrimidines were synthesized and found to have potent VEGF-R2 kinase inhibitory activity. Structure-activity relationships were investigated and compound 14a was shown to be efficacious in a mouse model of corneal neovascularization.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/17481894/