Peer-reviewed veterinary case report
Clear cell sweat gland tumor in 4-year-old female Golden Retriever
By Nibe, K et al.·Published in Veterinary pathology·2005·Department of Veterinary Pathology, Japan·View original on PubMed →
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Original publication title: A case of canine apocrine sweat gland adenoma, clear cell variant.
- Species:
- dog
Plain-English summary
A 4-year-old female Golden Retriever had a skin lump near her ear that was examined by a vet. After testing, it was found to be a type of tumor called an apocrine sweat gland adenoma, specifically the clear cell variant. The vet surgically removed the mass, and thankfully, there have been no signs of it coming back or spreading in the 18 months since the surgery. This type of tumor is rare in dogs, but the outcome was positive after treatment.
People also search for: dog skin lump near ear · Golden Retriever tumor removal · apocrine sweat gland adenoma in dogs
Abstract
A cutaneous mass at the base of the retroauricular region of a 4-year-old, female Golden Retriever was examined pathologically. Histologically, the mass formed multiple nodules consisting of a proliferation of large clear cells with abundant cytoplasm. Mitotic figures among the neoplastic cells were very sparse. The large clear cells were intensely positive for cytokeratins (AE1/AE4, cytokeratin 8 and 18) and moderately positive for lysozyme and contained periodic acid-Schiff-positive granules in the cytoplasm. In addition, small flat cells lined the islands of neoplastic large clear cells, and these were strongly positive for alpha-smooth muscle actin and vimentin, and some were positive for cytokeratin (AE1/AE4), suggesting they were myoepithelial cells. No local recurrence or metastasis has been recognized during the 18 months since surgical excision. On the basis of these findings, the present tumor was diagnosed as apocrine sweat gland adenoma, clear cell variant. There have been few previous reports of canine apocrine adenomas showing a clear cell morphology.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/15753476/