Peer-reviewed veterinary case report
Vincristine treatment results for transmissible venereal tumour
By Nak, D et al.·Published in Journal of veterinary medicine. A, Physiology, pathology, clinical medicine·2005·Department of Obstetrics and Gynecology·View original on PubMed →
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Original publication title: A Clinico-pathological study on the effect of vincristine on transmissible venereal tumour in dogs.
- Species:
- dog
Plain-English summary
A group of 38 dogs with transmissible venereal tumors (TVT), a type of tumor spread through sexual contact, were treated with a chemotherapy drug called vincristine. After receiving between two to seven doses, 31 dogs showed complete tumor regression. While one dog sadly died after the fifth dose and six needed an additional treatment, most dogs did well, with no tumor recurrences noted during follow-ups lasting up to 49 months. Vincristine proved to be an effective treatment for this condition, allowing many dogs to recover fully.
People also search for: dog transmissible venereal tumor treatment · vincristine for dog tumors · dog cancer chemotherapy options
Abstract
Transmissible venereal tumour (TVT) is a coitally transmitted neoplasm of dogs and is common among sexually active dogs, where sexual behaviour is not under control. Several treatment options are available for the treatment of the tumour, with chemotherapy being the most commonly employed. In this study, we investigated the clinical and cytological changes after weekly vincristine sulphate administration in 38 cases of naturally occurring TVT. Tumours totally regressed in 31 dogs after two to seven doses (mean 3.54 +/- 1.01) of vincristine. One dog died after the fifth dose of vincristine, and in six dogs, an additional treatment with doxorubicin was needed. Masses were still present in four dogs and the histopathological examination revealed small nodules of granulation tissue in two dogs, while viable tumour cells were identified in the remaining two cases. No recurrences were observed in a follow-up period of 7-49 months (mean 13.64 +/- 9.66); in one dog, granulation tissue was detected in the surgery site after 2 months. Treatment success could easily be followed by the cytological changes. In conclusion, vincristine was found to be effective chemotherapeutic agent.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/16109105/