Peer-reviewed veterinary case report
How a weight-loss program changes blood proteins in Beagle dogs
By Tvarijonaviciute, A et al.·Published in Domestic animal endocrinology·2012·Department of Animal Medicine and Surgery, Spain·View original on PubMed →
PetCaseFinder translated the abstract of this peer-reviewed paper into plain English so pet owners can read it. We do not publish original research — every detail traces back to the citation above. How we work →
Original publication title: A proteomic analysis of serum from dogs before and after a controlled weight-loss program.
- Species:
- dog
Plain-English summary
Five Beagle dogs were part of a weight-loss program to see how it affected their blood proteins. Before and after losing weight, their blood samples showed changes in certain proteins linked to obesity. Specifically, two proteins increased and one decreased after the dogs lost weight. These proteins could help identify obesity and related health issues in dogs. The study suggests that monitoring these proteins might be useful for managing weight-related health problems in pets.
People also search for: dog weight loss program · Beagle obesity treatment · dog blood protein changes · how to help my dog lose weight
Abstract
The objective of this study was to investigate how weight-loss program would alter the proteome of the serum of Beagle dogs. For this purpose, serum samples from 5 Beagle dogs, before and after weight loss, were analyzed using 2-dimensional electrophoresis. Protein profiles of all samples were obtained, divided into 2 classes (obese and lean), and compared using specific 2-dimensional software, giving a total of 144 spot matches. Statistical analysis revealed 3 spot matches whose expressions were modulated in response to weight loss: 2 protein spots were upregulated and 1 protein spot was downregulated in the obese state in comparison with the lean state of the dogs. Mass spectrometric identification of differentially regulated spots revealed that these protein spots corresponded to retinol-binding protein 4, clusterin precursor, and α-1 antitrypsin, respectively, which could be considered potential markers of obesity and obesity-related disease processes in dogs.
Find similar cases for your pet
PetCaseFinder finds other peer-reviewed reports of pets with the same symptoms, plus a plain-English summary of what was tried across them.
Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/22591953/