Peer-reviewed veterinary case report
Dog developed sudden liver failure after mitotane treatment
By Webb, Craig B & Twedt, David C·Published in Journal of the American Animal Hospital Association·2006·Department of Veterinary Clinical Sciences, United States·View original on PubMed →
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Original publication title: Acute hepatopathy associated with mitotane administration in a dog.
- Species:
- dog
Plain-English summary
A dog was given mitotane, a medication for suspected Cushing's disease, but after a month, it started showing signs of not wanting to eat and yellowing of the skin and eyes. Tests showed serious liver problems, including high liver enzymes and low blood sugar. Once the vet stopped the mitotane and provided supportive care, the dog began to recover and was back to normal in about three months. This case highlights the potential liver issues that can arise from mitotane treatment.
People also search for: dog yellow skin and eyes · dog not eating treatment · mitotane side effects in dogs
Abstract
An adult dog with a persistent elevation in alkaline phosphatase enzyme activity was started on mitotane for suspected hyperadrenocorticism. One month later, the dog was presented for intermittent anorexia and acute icterus. The dog's liver enzyme activities and total bilirubin were markedly elevated, prothrombin time was prolonged, and blood urea nitrogen and glucose were low. Histopathology revealed marked, centrilobular, hepatocellular loss. After discontinuation of the mitotane, the dog recovered with supportive care and was normal 3 months later, which was consistent with mitotane-associated hepatic failure.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/16822769/