Peer-reviewed veterinary case report
Acute hepatopathy associated with mitotane administration in a dog.
- Journal:
- Journal of the American Animal Hospital Association
- Year:
- 2006
- Authors:
- Webb, Craig B & Twedt, David C
- Affiliation:
- Department of Veterinary Clinical Sciences · United States
- Species:
- dog
Plain-English summary
A middle-aged dog was given a medication called mitotane to treat suspected Cushing's disease, which is caused by too much cortisol. After a month, the dog started to eat less and developed yellowing of the skin and eyes, a sign of liver problems. Tests showed that the dog's liver enzymes were very high, and there were issues with blood clotting and low levels of certain substances in the blood. A closer look at the liver tissue showed significant damage. Once the mitotane was stopped and the dog received supportive care, it made a full recovery and was back to normal after three months.
Abstract
An adult dog with a persistent elevation in alkaline phosphatase enzyme activity was started on mitotane for suspected hyperadrenocorticism. One month later, the dog was presented for intermittent anorexia and acute icterus. The dog's liver enzyme activities and total bilirubin were markedly elevated, prothrombin time was prolonged, and blood urea nitrogen and glucose were low. Histopathology revealed marked, centrilobular, hepatocellular loss. After discontinuation of the mitotane, the dog recovered with supportive care and was normal 3 months later, which was consistent with mitotane-associated hepatic failure.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/16822769/