Peer-reviewed veterinary case report
Adrenal necrosis in a dog receiving trilostane for the treatment of hyperadrenocorticism.
- Journal:
- The Journal of small animal practice
- Year:
- 2004
- Authors:
- Chapman, P S et al.
- Affiliation:
- Department of Clinical Studies · United States
- Species:
- dog
Plain-English summary
A 10-year-old male neutered Staffordshire bull terrier started showing signs of low adrenal function (hypoadrenocorticism) shortly after beginning treatment with trilostane for high adrenal hormone levels (hyperadrenocorticism). The dog became very tired and needed extra care, so he was given fluids and medications to help stabilize his condition. A surgery was performed to examine and remove part of the left adrenal gland, and tests showed that the gland had died off and was inflamed. This issue with trilostane causing adrenal necrosis (death of adrenal tissue) is something that hasn't been reported before, but with quick treatment, the dog's serious condition was managed successfully.
Abstract
Clinical and biochemical changes suggestive of hypoadrenocorticism were observed in a 10-year-old male neutered Staffordshire bull terrier shortly after beginning therapy with trilostane for the treatment of hyperadrenocorticism. The dog's condition was stabilised with intravenous fluids, fludrocortisone and prednisolone. An exploratory laparotomy and excisional biopsy of the left adrenal gland were performed. Histopathological analysis showed adrenal cortical necrosis with reactive inflammation and fibrosis. Trilostane is a reversible inhibitor of steroid synthesis and this complication has not been reported previously. Clinicians should be aware that trilostane therapy may result in adrenal necrosis but that prompt treatment might correct a life-threatening situation.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/15206477/