Peer-reviewed veterinary case report
Adrenal gland damage in dog treated with trilostane for Cushing's
By Chapman, P S et al.·Published in The Journal of small animal practice·2004·Department of Clinical Studies, United States·View original on PubMed →
PetCaseFinder translated the abstract of this peer-reviewed paper into plain English so pet owners can read it. We do not publish original research — every detail traces back to the citation above. How we work →
Original publication title: Adrenal necrosis in a dog receiving trilostane for the treatment of hyperadrenocorticism.
- Species:
- dog
Plain-English summary
A 10-year-old male neutered Staffordshire bull terrier developed symptoms of low adrenal function, like weakness and lethargy, shortly after starting trilostane for Cushing's disease (hyperadrenocorticism). The vet stabilized him with intravenous fluids and medications, including fludrocortisone and prednisolone. An exploratory surgery revealed damage to the adrenal gland, which was confirmed through a biopsy. Fortunately, with prompt treatment, the dog's condition improved, highlighting the importance of monitoring pets on trilostane for potential complications.
People also search for: dog weakness after trilostane · Staffordshire bull terrier adrenal problems · Cushing's disease treatment for dogs
Abstract
Clinical and biochemical changes suggestive of hypoadrenocorticism were observed in a 10-year-old male neutered Staffordshire bull terrier shortly after beginning therapy with trilostane for the treatment of hyperadrenocorticism. The dog's condition was stabilised with intravenous fluids, fludrocortisone and prednisolone. An exploratory laparotomy and excisional biopsy of the left adrenal gland were performed. Histopathological analysis showed adrenal cortical necrosis with reactive inflammation and fibrosis. Trilostane is a reversible inhibitor of steroid synthesis and this complication has not been reported previously. Clinicians should be aware that trilostane therapy may result in adrenal necrosis but that prompt treatment might correct a life-threatening situation.
Find similar cases for your pet
PetCaseFinder finds other peer-reviewed reports of pets with the same symptoms, plus a plain-English summary of what was tried across them.
Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/15206477/