Peer-reviewed veterinary case report
Rare bone-like skin melanoma in a dog found using S100 and melan
By Maliver, P et al.·Published in Journal of veterinary medicine. A, Physiology, pathology, clinical medicine·2004·Laboratoire d'Histocytopathologie Vé, France·View original on PubMed →
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Original publication title: An osteoid variant of cutaneous melanoma in a dog detected by S100 and melan a markers.
- Species:
- dog
Plain-English summary
A 10-year-old mixed-breed dog was diagnosed with a rare type of skin cancer called osteoid malignant melanoma, which can be aggressive and hard to identify. The tumor had some bone-like features, making it unique among skin tumors. To confirm the diagnosis, the veterinarian used special tests that highlighted specific markers in the tumor. This case is notable because it shows that this type of melanoma can start in the skin of dogs. Treatment options for this aggressive cancer may vary, so it's important to discuss the best approach with your veterinarian.
People also search for: dog skin cancer symptoms · malignant melanoma in dogs · osteoid melanoma treatment for dogs
Abstract
Osteoid malignant melanoma is a rare type of melanoma described in humans and dogs with some areas of bone differentiation. In this tumour, the origin of the bone matrix remains unclear. We report one case of this variant with, for the first time, a cutaneous origin in a dog. Malignant melanomas are aggressive tumours. Amelanotic tumours are sometimes difficult to recognize as they require immunohistochemical evaluation for an adequate diagnosis and we have used anti-vimentin, S100, and melan A antibodies for identification. Melan A is less sensitive but more specific than S100 in identifying amelanotic melanomas. This tumour was positive for vimentin, S100 and melan A, including the areas of osteoid. These results suggest osteoid differentiation of tumour cells rather than induced stromal metaplasia.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/15610483/