Peer-reviewed veterinary case report
Obesity linked to enzyme changes in dog breast cancer tumors
By Shin, J-I et al.·Published in Journal of comparative pathology·2016·Department of Veterinary Pathology, South Korea·View original on PubMed →
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Original publication title: Analysis of Obesity-Related Factors and their Association with Aromatase Expression in Canine Malignant Mammary Tumours.
- Species:
- dog
Plain-English summary
A study found that overweight and obese female dogs with malignant mammary tumors had higher levels of a substance called prostaglandin E2 (PGE2), which is linked to obesity. The research looked at various factors, including the dogs' weight, age, and neutering status, but did not find significant differences in tumor characteristics based on these factors. The findings suggest that obesity may play a role in the development of these tumors by affecting certain immune mediators. This highlights the importance of maintaining a healthy weight in dogs to potentially reduce the risk of developing malignant mammary tumors.
People also search for: dog mammary tumor treatment · overweight dog cancer risk · how to prevent obesity in dogs
Abstract
This study was designed to investigate the role of obesity in canine malignant mammary tumours (CMMTs), by assessing aromatase expression and the regulatory roles of immune mediators such as cyclo-oxygenase-2 (COX2), prostaglandin E2 (PGE2), nuclear factor kappa beta (NF-κB), hypoxia inducible factor-1α (HIF-1α) and adipokines (i.e. leptin) in lean, optimal body weight, overweight and obese animals. Clinicopathological data, including the breed, body weight, body condition score and age and neutering status, were collected, together with histopathological characteristics (i.e. histological types, grading and lymphatic invasion). To determine the expression of each factor, immunohistochemistry was conducted with 60 samples of malignant CMMTs. CMMTs from overweight and obese animals had significantly elevated levels of PGE2, and aromatase expression correlated significantly with PGE2, NF-κB and leptin expression. However, no significant difference was observed in terms of histopathological characteristics. The results suggest that PGE2, a known obesity-related immune mediator, could be upregulated in CMMTs from overweight and obese animals. In addition, PGE2, NF-κB and leptin influenced the expression of aromatase, as observed in women.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/27290646/