Peer-reviewed veterinary case report
Anti-histone antibodies linked to kidney disease in dogs
By Ginel, Pedro J et al.·Published in Research in veterinary science·2008·Department of Animal Medicine and Surgery, Spain·View original on PubMed →
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Original publication title: Anti-histone antibodies in dogs with leishmaniasis and glomerulonephritis.
- Species:
- dog
Plain-English summary
A group of dogs with leishmaniasis (a parasitic infection) were tested for kidney problems, specifically glomerulonephritis, which can cause increased creatinine levels and protein in urine. The study found that nearly 90% of the dogs with kidney issues had high levels of anti-histone antibodies, which are markers that could indicate kidney damage. In contrast, only about 39% of dogs without kidney problems showed elevated antibodies. This suggests that if a dog with leishmaniasis has high anti-histone antibodies, it may be more likely to develop kidney issues.
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Abstract
The association between serum anti-histone antibodies and glomerulonephritis was studied in 43 dogs with leishmaniasis (Leishmania infantum). Dogs with increased serum creatinine levels and urine protein-creatinine ratio >1 were considered to have glomerulonephritis. Moderately elevated anti-histone antibodies were found in 38.89% (7/18) of infected dogs without glomerulonephritis, whereas 88% of dogs with glomerulonephritis (22/25) showed moderate or strongly elevated anti-histone antibodies. Prevalence of positive anti-histone antibodies reactions and mean serum concentration was significantly higher (P<0.001; P<0.0001) in infected dogs with glomerulonephritis. Correlation between anti-histone antibodies and urine protein-creatinine ratio was significant when groups were analysed together (P<0.046). Positive predictive value for glomerulonephritis of positive anti-histone antibodies was 88%. In conclusion, high anti-histone antibodies are significantly associated with glomerulonephritis. Although other factors must be involved, dogs with moderate or strong positive anti-histone antibodies reactions may have a higher probability to develop glomerular lesions in canine leishmaniasis.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/18321541/