Peer-reviewed veterinary case report
Anti-insulin antibodies in diabetic dogs before and after insulin
By Davison, L J et al.·Published in Journal of veterinary internal medicine·2008·Department of Pathology and Infectious Diseases, United Kingdom·View original on PubMed →
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Original publication title: Anti-insulin antibodies in diabetic dogs before and after treatment with different insulin preparations.
- Species:
- dog
Plain-English summary
A group of diabetic dogs was tested for anti-insulin antibodies (AIA) before and after receiving different types of insulin. The study found that while some untreated diabetic dogs had AIA, those treated with bovine insulin were much more likely to develop these antibodies compared to those treated with porcine insulin. Specifically, 90% of dogs treated with bovine PZI insulin and 56% treated with bovine lente insulin showed AIA, while there was no significant difference in AIA for dogs treated with porcine insulin. This suggests that bovine insulin may trigger a stronger immune response in diabetic dogs.
People also search for: diabetic dog insulin treatment · anti-insulin antibodies in dogs · bovine vs porcine insulin for dogs
Abstract
BACKGROUND: Anti-insulin antibodies (AIA) occur in diabetic dogs after insulin therapy, although their clinical significance is unclear. HYPOTHESIS: Treatment of diabetic dogs with heterologous insulin is more likely to stimulate production of AIA than is treatment with homologous insulin. ANIMALS: Diabetic dogs sampled before insulin therapy (n = 40), diabetic dogs sampled following treatment with porcine (homologous) insulin (n = 100), bovine (heterologous) lente insulin (n = 100), or bovine protamine zinc (PZI) insulin (n = 20), and nondiabetic control dogs (n = 120). METHODS: Prospective observational study. Sera were analyzed by ELISA for antibodies against porcine insulin, bovine insulin, insulin A, B, or C peptides, and control antigens; canine distemper virus (CDV) and canine thyroglobulin (TG). Canine isotype-specific antibodies were used to determine total and anti-insulin IgG1 : IgG2 ratios. RESULTS: There was no difference in CDV or TG reactivity among the groups. AIA were detected in 5 of 40 newly diagnosed (untreated) diabetic dogs. There was no significant difference in AIA (ELISA optical density reactivity) comparing control and porcine insulin-treated diabetic dogs (P > .05). Anti-insulin reactivity was most prevalent in bovine PZI insulin-treated dogs (90%; P < .01), and bovine lente insulin-treated dogs (56%; P < .01). AIA induced by treatment were enriched for the IgG1 isotype. CONCLUSIONS AND CLINICAL IMPORTANCE: This study indicates that bovine insulin is more immunogenic than porcine insulin when used for treatment of diabetic dogs.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/18976287/