Peer-reviewed veterinary case report
Anti-Muellerian hormone levels in dogs with ovarian tumors and cysts
By Walter, B et al.·Published in Reproduction in domestic animals = Zuchthygiene·2018·Faculty of Veterinary Medicine, Germany·View original on PubMed →
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Original publication title: Anti-Muellerian hormone concentration in bitches with histopathologically diagnosed ovarian tumours and cysts.
- Species:
- dog
Plain-English summary
A group of female dogs with ovarian issues were tested for a hormone called Anti-Muellerian hormone (AMH) to see if it could help identify those with a specific type of tumor called a granulosa cell tumor. The study found that dogs with granulosa cell tumors had significantly higher AMH levels compared to those with normal ovaries or other types of ovarian cysts. While high AMH levels can indicate the presence of this tumor, normal levels don't completely rule it out. This information can help veterinarians diagnose and treat ovarian tumors more effectively.
People also search for: dog ovarian tumor symptoms · granulosa cell tumor in dogs · high AMH levels in dogs
Abstract
Increased concentrations of Anti-Muellerian hormone (AMH) can indicate a granulosa cell tumour as shown in women, mares and cows. To investigate AMH to differentiate canine granulosa cell tumour from other ovarian pathologies, we evaluated the ovaries of 63 bitches. Blood serum samples were collected before surgery for AMH analysis. Ovaries were submitted for histopathological examination. Fourteen bitches showed normal ovaries. These bitches had AMH values between 0.12 and 0.99 ng/ml. In 20 bitches ovarian cysts i.e., follicular cysts (n = 8), corpora lutea cysts (n = 7), subsurface cysts (n = 5) were diagnosed. These dogs had AMH values of 0.11-2.09 ng/ml. Bitches with small luteinized follicular cysts had slightly higher AMH values than those without ovarian alteration. In 29 cases ovarian neoplasms i.e., granulosa cell tumour (n = 9), epithelial tumours (n = 16), dysgerminomas (n = 3) and one sarcoma were identified. Anti-Muellerian hormone values of bitches with an ovarian neoplasm except granulosa cell tumour ranged from 0.18 to 1.18 ng/ml. The AMH values of bitches with granulosa cell tumour ranged from 1.12 to ≤23 ng/ml and were significantly higher (p < .05) than in all of the other bitches. The cut-off of 0.99 ng/ml gave a sensitivity of 100% and a specificity of 94.44% to diagnose granulosa cell tumour. In conclusion, markedly elevated AMH concentrations in bitches are indicative for a granulosa cell tumour. However, negative testing does not rule out the existence of small one. Differentiation of GCT from luteinized follicular cysts may especially be difficult.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/29603438/