Peer-reviewed veterinary case report
Platelet levels linked to blood sugar control in diabetic dogs
By Tsouloufi, Theodora K et al.·Published in Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·2022·School of Veterinary Medicine·View original on PubMed →
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Original publication title: Association of platelet indices with glycemic status in diabetic dogs.
- Species:
- dog
Plain-English summary
A group of 14 dogs with newly diagnosed type 1 diabetes was studied to see how their blood platelet levels compared to healthy dogs. The diabetic dogs had higher platelet counts and plateletcrit (a measure of the volume of platelets in the blood) than the healthy dogs, indicating a potential issue with blood cell production related to their diabetes. While the average size of the platelets didn't differ significantly, there was a weak link between higher blood sugar levels and increased platelet counts. This suggests that diabetic dogs may have changes in their blood that could affect their health, but more research is needed to understand the full impact.
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Abstract
We investigated the platelet count (PLT), mean platelet volume (MPV), and plateletcrit (PCT) in dogs with type 1 diabetes mellitus (DM) compared to healthy controls, and their association with the major fraction of glycated hemoglobin (HbA1c). Blood samples from 33 clinically healthy dogs and 14 newly diagnosed diabetic dogs were included. CBCs were performed with the Advia 120; HbA1c was determined using a validated assay (Capillarys 2 flex-piercing; Sebia). Median [range] PLT and PCT were significantly higher ( = 0.040 and = 0.010, respectively) in diabetic dogs (434 [176-987] × 10/L and 0.60 [0.26-1.22]%, respectively) compared to healthy dogs (297 [223-671] × 10/L and 0.35 [0.24-0.87]%, respectively]. Thrombocytosis was observed in 6 of 14 (43%) diabetic dogs. The median MPV was not significantly different ( = 0.114) between the diabetic (13.6 fL, 10.1-22.6 fL) and healthy dogs (11.9 fL, 8.6-19.1 fL). A significant, albeit weak, correlation was detected between HbA1c and PLT (rho = 0.298, = 0.042) and PCT (rho = 0.340, = 0.019), but no significant correlation was found with MPV (rho = 0.199, = 0.180). Canine DM was associated with increased PLT and PCT, which was correlated with glycemic status. Our findings suggest dysregulated megakaryopoiesis in diabetic dogs, but this should be confirmed by large-scale studies, and the clinical implications should be investigated.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/35655439/