Peer-reviewed veterinary case report
Rare mammary tumor with cystic ducts in a Miniature Pinscher dog
By Yasuno, Kyohei et al.·Published in The Journal of veterinary medical science·2013·Research Institute of Biosciences, Japan·View original on PubMed →
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Original publication title: Atypical canine mammary adenoma characterized by cystic ducts comprising a single layer of basaloid cells with myoepithelial differentiation.
- Species:
- dog
Plain-English summary
A 9-year-old female Miniature Pinscher was brought in with mammary tumors on her chest. The vet found that one of the tumors had unusual features, including cystic ducts made up of specific types of cells. After testing, it was determined that the tumor likely originated from certain cells in the mammary tissue. While the report focuses on the tumor's characteristics, it’s important for pet owners to know that tumors like this can vary widely in behavior and treatment options. If your pet has similar symptoms, consult your veterinarian for the best course of action.
People also search for: dog mammary tumor treatment · Miniature Pinscher breast lumps · what to do about dog tumors
Abstract
This report describes an atypical mammary adenoma with a rare histological feature characterized by proliferating single-layered cystic ducts composed of basaloid cells with frequent myoepithelial differentiation. A 9-year-old, intact female Miniature Pinscher dog had mammary tumors on the thorax. Histologically, one of tumors comprised the proliferation of two types of tubular structures; the single-layered cystic ducts lined by flattened cells and double-layered tubules with luminal cells and outer spindle cells. The former ducts were predominant in the tumor and contained pale basophilic mucus, which was Alcian blue (pH 2.5)-positive, but periodic acid Schiff-negative. Immunohistochemical staining indicated that the cells lining single-layered cystic ducts were negative for the luminal epithelial marker, cytokeratin (CK) CAM5.2, but were constantly positive for basal cell markers CK14 and p63 and frequently positive for SMA. Electron microscopy revealed fine, parallel myofilaments within these single-layered neoplastic cells. These histological and immunohistological examinations suggested that the origin of the tumor was bipotential mammary progenitor cells with predominant differentiation into the myoepithelial progenitor linage.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/23546686/