Peer-reviewed veterinary case report
New drug combo shows promise against canine breast cancer tumors
By Lin, Zhaoyan et al.·Published in Frontiers in veterinary science·2021·Department of Veterinary Clinical Sciences, China·View original on PubMed →
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Original publication title: Auranofin and ICG-001 Emerge Synergistic Anti-tumor Effect on Canine Breast Cancer by Inducing Apoptosis via Mitochondrial Pathway.
- Species:
- dog
Plain-English summary
A study found that a combination of two drugs, Auranofin and ICG-001, showed promise in treating canine breast cancer, which is the most common tumor in female dogs. This combination worked by inducing cell death through damage to the mitochondria, the energy-producing parts of the cells. While these drugs are not yet standard treatments, their ability to work together could offer new hope for dogs diagnosed with this type of cancer. More research is needed, but this could be a potential option for veterinarians to consider in the future.
People also search for: dog breast cancer treatment · Auranofin for dogs · ICG-001 canine cancer therapy
Abstract
Canine breast cancer (CBC) is the most common spontaneous tumor in intact female dogs, especially in developing countries. The effective anti-tumor agents or therapies for the clinical treatment of CBC are still in need. Auranofin (AF) is a gold complex that has been attested by FDA for treating human rheumatism, which has been found as a great anti-tumor agent in recent years. ICG-001 is a small molecule inhibitor of Wnt/β-catenin pathway. In the present study, we demonstrated that a combination of AF and ICG-001 could synergistically suppress the proliferation of CBCand. Moreover, the synergistical effect was related with apoptosis caused by mitochondrial damage and ROS production. In conclusion, combination of AF and ICG-001 could synergistically suppress the growth of CBCandby leading apoptosis via mitochondrial signaling pathway and might provide a novel potential choice for the clinical treatment of CBC.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/34977210/