Peer-reviewed veterinary case report
Auranofin slows growth of canine mammary tumor cells by triggering
By Lin, Zhaoyan et al.·Published in Veterinary and comparative oncology·2024·College of Animal Science, China·View original on PubMed →
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Original publication title: Auranofin Suppresses the Growth of Canine Mammary Tumour Cells and Induces Apoptosis via the PI3K/AKT Pathway.
- Species:
- dog
Plain-English summary
A study found that auranofin, a gold compound typically used for treating rheumatism, may help fight canine mammary tumors in female dogs. Researchers tested auranofin on various canine mammary tumor cell lines and discovered it effectively slowed tumor growth, migration, and invasion, while also causing cancer cell death through a specific cellular pathway. This suggests that auranofin could be a promising treatment option for dogs with mammary tumors, although further research is needed to confirm its effectiveness in live patients.
People also search for: dog mammary tumor treatment · auranofin for canine cancer · female dog tumor symptoms
Abstract
Canine mammary gland tumour (CMT) is the most common spontaneous tumour in intact female dogs and often exhibits metastases. Auranofin (AF) is a gold complex used for treating rheumatism. The excellent anti-tumour ability of AF has been demonstrated in various types of human and canine tumours. In this study, five CMT cell lines (CIPp, CMT-7364, CHMp, CIPm and CTBp) and three CMT primary cells (G7894, L1883 and L6783) were used to explore the anti-tumour effect of AF on CMT. Two CMT cell lines (CIPp and CMT-7364) were used to search the underlying mechanism of the effect of AF on CMT. The results showed that AF inhibited the growth, migration, invasion, and colony formation abilities of CMT cells. Additionally, the growth of CMT in a 3D cell culture model was effectively suppressed by AF. Furthermore, AF induced cell apoptosis of CMT cells via the PI3K/AKT pathway. In conclusion, AF effectively induces CMT apoptosis by regulating the PI3K/AKT pathway, indicating that AF should be explored as a potential CMT treatment in future studies.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/39221701/