Peer-reviewed veterinary case report
Bacterial Biogeography of the Colon in Dogs With Chronic Inflammatory Enteropathy.
- Journal:
- Veterinary pathology
- Year:
- 2020
- Authors:
- Giaretta, Paula R et al.
- Affiliation:
- Department of Veterinary Pathobiology · United States
- Species:
- dog
Plain-English summary
This study looked at the bacteria in the intestines of dogs with chronic inflammatory enteropathy (CIE), a condition similar to inflammatory bowel disease in humans. Researchers compared the gut bacteria of 22 dogs with CIE to 11 healthy dogs. They found that the total number of bacteria was lower in the intestines of dogs with CIE, and certain types of bacteria were also reduced. However, some other types of bacteria were found in higher numbers in the dogs with CIE. Overall, the study showed that the gut bacteria in dogs with CIE were different from those in healthy dogs, particularly with fewer bacteria in the deeper parts of the intestinal lining.
Abstract
The intestinal microbiota is believed to play a role in the pathogenesis of inflammatory bowel disease in humans and chronic inflammatory enteropathy (CIE) in dogs. While most previous studies have described the gut microbiota using sequencing methods, it is fundamental to assess the spatial distribution of the bacteria for a better understanding of their relationship with the host. The microbiota in the colonic mucosa of 22 dogs with CIE and 11 control dogs was investigated using fluorescence in situ hybridization (FISH) with a universal eubacterial probe (EUB338) and specific probes for select bacterial groups. The number of total bacteria labeled with EUB338 probe was lower within the colonic crypts of dogs with CIE compared to controls.spp. andspp. were decreased on the colonic surface and in the crypts of dogs with CIE. Dogs with CIE had increased number ofspp. on the colonic surface and within the crypts compared to control dogs. In conclusion, the bacterial microbiota in the colonic mucosa differed between dogs with and without CIE, with depletion of the crypt bacteria in dogs with CIE. The crypt bacterial species that was intimately associated with the host mucosa in control dogs was composed mainly ofspp.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/31916499/