Peer-reviewed veterinary case report
Benign mixed mammary tumor with liver-like cells in a dog
By Otsuka, Narumi et al.·Published in Journal of comparative pathology·2022·Joint Graduate School of Veterinary Sciences, Japan·View original on PubMed →
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Original publication title: Benign Mixed Mammary Tumour with Hepatoid Gland Differentiation in a Dog.
- Species:
- dog
Plain-English summary
A 10-year-old spayed female Shih Tzu had surgery to remove a small tumor from her right mammary gland. The tumor was found to be a benign mixed type, containing different cell types, including some that resembled normal hepatoid gland cells. After the surgery, the dog recovered well, and there were no signs of further issues. This case is notable as it is the first report of this specific type of mammary tumor in dogs.
People also search for: dog mammary tumor surgery · Shih Tzu tumor removal · benign mammary tumor in dogs
Abstract
A 10-year-old spayed female Shih Tzu underwent surgery to remove a tumour (8 mm diameter) in the right 4mammary gland. Histopathologically, the tumour consisted of four different components: luminal epithelial cells, myoepithelial cells, cartilage and well-differentiated hepatoid gland-like cells. There were multiple nests composed predominantly of hepatoid gland-like tissue with a small number of tubules formed by luminal epithelial cells at the periphery, in which continuity between the two components was seen. Immunolabelling for cytokeratins (CK14, CK18 and CK19), p63 and α-smooth muscle actin clearly distinguished the neoplastic luminal epithelial, myoepithelial and hepatoid gland-like cells. The immunohistochemical phenotype of the hepatoid gland-like neoplastic cells was identical to that of normal hepatoid gland cells. Based on these findings, a diagnosis of benign mixed tumour of the mammary gland with differentiated hepatoid gland cells was made. To our knowledge, this is the first report of a canine mammary tumour with hepatoid gland differentiation.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/36089294/