Peer-reviewed veterinary case report
Bilateral ovarian malignant mixed Mullerian tumor in a 10-year-old dog
By Antuofermo, E et al.·Published in Veterinary pathology·2009·Department of Pathology and Veterinary Clinic, Italy·View original on PubMed →
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Original publication title: Bilateral ovarian malignant mixed Mullerian tumor in a dog.
- Species:
- dog
Plain-English summary
A 10-year-old female dog was diagnosed with a rare type of cancer called a malignant mixed Müllerian tumor (MMMT) affecting both ovaries. The dog showed only moderate enlargement of the ovaries, but unfortunately, the cancer had spread to her abdomen and lungs. The tumor contained both cancerous and sarcomatous (soft tissue) components, which made treatment more complex. Due to the aggressive nature of this tumor and its metastases, the prognosis was poor. Treatment options for this type of cancer can be limited, and the dog may require specialized care.
People also search for: dog ovarian cancer symptoms · female dog tumor treatment · what is malignant mixed Müllerian tumor in dogs
Abstract
Malignant mixed Müllerian tumor (MMMT) is a rare neoplasm of the female genital tract. We report a case of bilateral ovarian MMMT in a 10-year-old female dog. Ovaries were only moderately enlarged with a papillary surface and firm nodules. Multiple metastases were observed in the abdominal cavity and pulmonary parenchyma. Histologically, both ovaries had intermingled carcinomatous and sarcomatous components with cartilage and bone. Metastatic lesions were not mixed. The peritoneal metastases were carcinomatous; pulmonary metastases were sarcomatous. Carcinomatous elements of the MMMT were immunohistochemically positive for cytokeratin (CK) AE1/AE3, CK7, and vimentin and estrogen receptors. Conversely, the sarcomatous cells were positive for vimentin, but negative for CKs. Chondrocytes also expressed S-100 protein. On the basis of similarities to human ovarian MMMT, the diagnosis was heterologous malignant mixed Müllerian tumor of the ovary.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/19176505/