Peer-reviewed veterinary case report
Electrochemotherapy with bleomycin helps resistant genital tumors
By Spugnini, Enrico P et al.·Published in Journal of experimental & clinical cancer research : CR·2008·SAFU Department, Italy·View original on PubMed →
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Original publication title: Biphasic pulses enhance bleomycin efficacy in a spontaneous canine genital tumor model of chemoresistance: Sticker sarcoma.
- Species:
- dog
Plain-English summary
Three dogs with a stubborn genital tumor called Sticker's sarcoma (or transmissible venereal tumor) were treated with a new method combining chemotherapy and electric pulses. After receiving bleomycin injections, the dogs underwent electrochemotherapy, which involved delivering electric pulses to enhance the drug's effectiveness. All three dogs responded well to the treatment and are currently in remission. This approach shows promise as a safe and effective option for treating this type of tumor in dogs.
People also search for: dog genital tumor treatment · Sticker's sarcoma in dogs · electrochemotherapy for dog tumors
Abstract
Sticker's sarcoma (also known as transmissible venereal tumor) is a horizontally transmitted neoplasm of the dog, that is passed with coitus. It is a locally aggressive tumor with a low tendency to metastatic spread. The most common locations are the genitals, the nose, the perianal area. Standard treatment consists with chemotherapy with vincristine, however other therapies such as, cryotherapy, immunotherapy or, in selected cases, radiation therapy, have been reported. In this article we describe the outcome of a small cohort of canine patients, with chemotherapy resistant transmissible venereal tumor (TVT), treated with bleomycin selectively driven by trains of biphasic pulses (electrochemotherapy). Three canine patients, with refractory TVT, entered the study and received two sessions of ECT under sedation. The pets had local injection of bleomycin at the concentration of 1.5 mg/ml and five minutes after the chemotherapy, trains of 8 biphasic electric pulses lasting 50 + 50 mus each, with 1 ms interpulse intervals, were delivered by means of modified caliper or, for difficult districts, through paired needle electrode. All the patients responded to the treatment and are still in remission at different times. Electrochemotherapy appears as a safe and efficacious modality for the treatment of TVT and warrants further investigations.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/18980687/