Peer-reviewed veterinary case report
Bleomycin with biphasic pulses improves treatment of dog perianal
By Spugnini, E P et al.·Published in Journal of experimental & clinical cancer research : CR·2007·S.A.F.U. Department, Italy·View original on PubMed →
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Original publication title: Biphasic pulses enhance bleomycin efficacy in a spontaneous canine perianal tumors model.
- Species:
- dog
Plain-English summary
A group of 12 dogs with perianal tumors, including both adenomas and carcinomas, were treated with a combination of chemotherapy using bleomycin and a special technique called electrochemotherapy. This involved injecting bleomycin and then applying electric pulses to enhance the treatment's effectiveness. The results were promising, with 91% of the dogs responding positively to the treatment and 83% achieving complete remission. Most dogs showed significant improvement, with one dog maintaining a positive response for 12 months. This method appears to be a safe and effective option for treating these types of tumors in dogs.
People also search for: dog perianal tumor treatment · bleomycin for dog tumors · electrochemotherapy for canine cancer
Abstract
Perianal tumors (adenoma and carcinoma of the hepatoid glands) are frequently reported in veterinary literature. They are locally aggressive tumors with a low tendency to metastatic spread. An hormonal ethiology has been identified for the development of perianal adenomas in male dogs, while the carcinomas are free from hormonal influence. Standard treatments include surgery, cryotherapy or, in selected cases, radiation therapy. In this article we describe the outcome of a small cohort of canine patients with perianal tumors treated with bleomycin selectively driven by trains of biphasic pulses (electrochemotherapy). Twelve canine patients, eight with adenoma and four with carcinoma of the perianal glands, entered the study and received two sessions of ECT under sedation. The pets had local injection ofbleomycin at the concentration of 1.5 mg/mg and five minutes after the chemotherapy, trains of 8 biphasic electric pulses lasting 50 + 50 micros each, with 1 ms interpulse intervals, were delivered by means of modified caliper and needle array electrodes or, for difficult districts, through paired needle electrode. The overall response rate was 91% with a 83% of complete response (10/12); one dog had a PR that lasted 12 months and another had progressive disease. Electrochemotherapy appears as a safe and efficacious modality for the treatment of perianal tumors and warrants further investigations.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/18365542/