Peer-reviewed veterinary case report
Breed and age differences in dog mammary tumors in Korea
By Kim, Hyun-Woo et al.·Published in Canadian journal of veterinary research = Revue canadienne de recherche veterinaire·2016·Department of Veterinary Pathology, South Korea·View original on PubMed →
PetCaseFinder translated the abstract of this peer-reviewed paper into plain English so pet owners can read it. We do not publish original research — every detail traces back to the citation above. How we work →
Original publication title: Breed- and age-related differences in canine mammary tumors.
- Species:
- dog
Plain-English summary
A study found that older female Shih Tzus are more likely to develop a specific type of breast cancer called basal-like triple-negative mammary carcinoma. Out of the dogs examined, a significant number of these tumors were found in Shih Tzus and in dogs of advanced age. This type of cancer is known for being aggressive and difficult to treat. If you have an older Shih Tzu, it's important to keep an eye on any changes in their health and discuss any concerns with your veterinarian. Early detection can be crucial for better outcomes.
People also search for: Shih Tzu breast cancer symptoms · dog mammary tumor treatment · older dog cancer signs
Abstract
Triple-negative breast cancer is a type of breast cancer that does not express the genes for estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor-2 (HER-2). It is an important and clinically relevant condition as it has a poor prognosis and is difficult to treat. Basal-like triple-negative cancer is highly prevalent in both African-Americans and adolescents. We therefore examined whether such a cancer likewise occurs in specific breeds and age groups in dogs, focusing on basal-like triple-negative cancer in particular. In this study, 181 samples from dogs with malignant mammary carcinoma from the 5 most common breeds and 2 age groups in Korea were analyzed. Histological classification and molecular subtyping, including assessment of immunohistochemical findings, were carried out. Twenty-five of 28 (89.3%) triple-negative carcinomas were identified as basal-like triple-negative carcinomas. Analysis of associations of classified factors revealed that the shih tzu breed (9/25, 36.0%) and advanced-age (19/25, 76.0%) groups were characterized by higher prevalence of basal-like triple-negative tumors with diverse histological types and of a higher grade. These results suggest that breed- and age-related differences can be identified in canine mammary carcinoma and, notably, in the shih tzu breed and at older ages. Further investigation of these distinguishing characteristics of the shih tzu breed is warranted.
Find similar cases for your pet
PetCaseFinder finds other peer-reviewed reports of pets with the same symptoms, plus a plain-English summary of what was tried across them.
Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/27127342/