Peer-reviewed veterinary case report
Gene linked to obesity found in both dogs and humans
By Wallis, Natalie J et al.·Published in Science (New York, N.Y.)·2025·Department of Physiology, United Kingdom·View original on PubMed →
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Original publication title: Canine genome-wide association study identifiesas an obesity gene in dogs and humans.
- Species:
- dog
Plain-English summary
A study found that a specific gene in Labrador retrievers is linked to obesity, which could help explain why some dogs gain weight more easily than others. Researchers looked at 241 Labradors and discovered that a certain version of the DENN domain containing 1B gene was associated with about 7.5% more body fat. This gene plays a role in how the body manages energy and fat storage. Understanding these genetic factors could lead to better ways to manage weight in both dogs and humans.
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Abstract
Obesity is a heritable disease, but its genetic basis is incompletely understood. Canine population history facilitates trait mapping. We performed a canine genome-wide association study for body condition score-a measure of obesity-in 241 Labrador retrievers. Using a cross-species approach, we showed that canine obesity genes are also associated with rare and common forms of obesity in humans. The lead canine association was within the gene DENN domain containing 1B (). Each copy of the alternate allele was associated with ~7.5% greater body fat. We demonstrate a role for this gene in regulating signaling and trafficking of melanocortin 4 receptor, a critical controller of energy homeostasis. Thus, canine genetics identified obesity genes and mechanisms relevant to both dogs and humans.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/40048553/