Peer-reviewed veterinary case report
Plasma cell tumors in dog windpipe and voice box cases and review
By Mulka, Kathleen R et al.·Published in Veterinary pathology·2025·University of Pennsylvania, United States·View original on PubMed →
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Original publication title: Canine laryngotracheal plasma cell tumors: Ten cases and literature review.
- Species:
- dog
Plain-English summary
A group of male dogs aged 7 to 15 years was diagnosed with plasma cell tumors in the larynx and trachea, which can cause breathing problems. After surgery to remove the tumors, most of the dogs showed no signs of recurrence or disease progression for up to 7 years. This suggests that surgical removal can be an effective treatment for these types of tumors. If your dog is experiencing any unusual breathing issues, it's important to consult your veterinarian for a thorough evaluation.
People also search for: dog breathing problems · laryngeal tumor in dogs · plasma cell tumor treatment in dogs
Abstract
Canine extramedullary plasma cell tumors (EMPs) most commonly arise in the skin, oral cavity, rectum, and colon. This retrospective study describes the histopathological and immunohistochemical characteristics and associated clinical signs and outcomes of laryngeal and tracheal EMPs in dogs. Five tracheal and 5 laryngeal EMPs were diagnosed at the Penn Vet Diagnostic Laboratory. Clinical information was obtained via submission forms and follow-up questionnaires. All dogs were male (9 castrated), 7 to 15 years old, and of different breeds. Neoplasms were composed of well-differentiated (n = 6) or moderately differentiated (n = 4) neoplastic plasma cells arranged in sheets, cords, and packets. All neoplasms labeled positively for MUM-1, negatively for PAX5, and were variably CD20- and CD79b-positive. There was no recurrence or disease progression 2 months to 7 years post biopsy in 6/9 cases. Results suggest that surgical resection can result in positive outcomes. Further studies are needed to identify factors leading to progression of this disease.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/40215400/