Peer-reviewed veterinary case report
Survival in female dogs with advanced mammary tumors
By Lavalle, Gleidice Eunice et al.·Published in In vivo (Athens, Greece)·2012·Department of General Pathology, Brazil·View original on PubMed →
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Original publication title: Canine malignant mammary gland neoplasms with advanced clinical staging treated with carboplatin and cyclooxygenase inhibitors.
- Species:
- dog
Plain-English summary
A group of 29 female dogs with advanced mammary tumors underwent surgery and were treated with different combinations of chemotherapy and anti-inflammatory medications. The study found that dogs with lower levels of a specific protein (COX-2) had longer survival times compared to those with higher levels. Adding these treatments to surgery significantly improved overall survival compared to surgery alone. This suggests that using a combination of therapies can be beneficial for dogs with serious mammary tumors.
People also search for: dog mammary tumor treatment · female dog cancer survival · COX-2 inhibitors for dogs · chemotherapy for dog tumors
Abstract
Surgery remains the treatment of choice for female dogs with mammary gland tumors. Chemotherapy is not commonly used as an adjuvant therapy. Cyclooxygenase 2 (COX-2) has been related to angiogenesis development in tumors, disease progression and worse prognosis. The aim of this prospective study was to compare overall survival periods of female dogs diagnosed with advanced mammary tumors submitted to different treatment protocols, including surgery, chemotherapy and cyclooxygenase inhibitors. Twenty-nine female dogs were evaluated and treated with four different protocols. The overall survival of patients with low COX-2 scores was longer when compared to patients with high COX-2 scores. Different proposed adjuvant treatments associated with surgery led to a statistically significant longer overall survival when compared to surgical treatment alone. Canine patients presenting malignant mammary gland neoplasms with advanced clinical staging should be submitted to complementary therapeutic medication based on clinical staging and immunophenotypical characteristics of the disease.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/22523289/