Peer-reviewed veterinary case report
Collagen fiber patterns linked to tumor behavior and survival in dog
By Ana P. V. Garcia et al.·Published in Scientific Reports·2021·Laboratório de Patologia Comparada, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, GB·View original on DOAJ →
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Original publication title: Canine mammary cancer tumour behaviour and patient survival time are associated with collagen fibre characteristics
- Species:
- dog
Plain-English summary
A study looked at 45 dogs with mammary cancer to see how changes in collagen fibers in tumors could help predict how the cancer behaves and how long the dogs might live. The researchers found that tumors with shorter and more aligned collagen fibers were linked to a poorer survival rate. This means that examining the collagen in cancer biopsies could provide valuable information for diagnosing and determining the prognosis for dogs with mammary cancer. Understanding these characteristics may help veterinarians better manage treatment options for affected pets.
People also search for: dog mammary cancer prognosis · canine mammary tumor treatment · how long can a dog live with mammary cancer
Abstract
Abstract Precise diagnosis and prognosis are key in prevention and reduction of morbidity and mortality in all types of cancers. Here we show that changes in the collagen fibres in the main histological subtypes of canine mammary gland carcinomas are directly associated with the tumour behaviour and the animal survival time and could become a useful tool in helping with diagnosis. Imaging by second harmonic generation and multiphoton excited fluorescence microscopy were performed to evaluate the collagen and cellular segment parameters in cancer biopsies. We present a retrospective study of 45 cases of canine mammary cancer analysing 836 biopsies regions including normal mammary gland tissue, benign mixed tumours, carcinoma in mixed tumour, carcinosarcoma, micropapillary carcinoma and solid carcinoma. The image analyses and the comparison between the tumour types allowed to assess the collagen fibre changes during tumour progression. We demonstrate that the collagen parameters correlate with the clinical and pathological data, the results show that in neoplastic tissues, the collagen fibres are more aligned and shorter as compared to the normal tissues. There is a clear association of the mean fibre length with the dogs survival times, the carcinomas presenting shorter collagen fibres indicate a worse survival rate.
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Search related cases →Original publication on DOAJ: https://doi.org/10.1038/s41598-021-85104-w