Peer-reviewed veterinary case report
Collagen fiber patterns linked to tumor behavior and survival in dog
By Garcia, Ana P V et al.·Published in Scientific reports·2021·Laborató, Brazil·View original on PubMed →
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Original publication title: Canine mammary cancer tumour behaviour and patient survival time are associated with collagen fibre characteristics.
- Species:
- dog
Plain-English summary
A study looked at 45 dogs with mammary cancer (breast cancer) to understand how changes in collagen fibers in the tumors might affect the dogs' survival times. The researchers found that tumors with shorter and more aligned collagen fibers were linked to a poorer prognosis, meaning these dogs had a lower chance of surviving longer. This information could help veterinarians make better diagnoses and treatment plans for dogs with mammary cancer. Understanding these collagen characteristics may lead to improved outcomes for affected pets.
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Abstract
Precise diagnosis and prognosis are key in prevention and reduction of morbidity and mortality in all types of cancers. Here we show that changes in the collagen fibres in the main histological subtypes of canine mammary gland carcinomas are directly associated with the tumour behaviour and the animal survival time and could become a useful tool in helping with diagnosis. Imaging by second harmonic generation and multiphoton excited fluorescence microscopy were performed to evaluate the collagen and cellular segment parameters in cancer biopsies. We present a retrospective study of 45 cases of canine mammary cancer analysing 836 biopsies regions including normal mammary gland tissue, benign mixed tumours, carcinoma in mixed tumour, carcinosarcoma, micropapillary carcinoma and solid carcinoma. The image analyses and the comparison between the tumour types allowed to assess the collagen fibre changes during tumour progression. We demonstrate that the collagen parameters correlate with the clinical and pathological data, the results show that in neoplastic tissues, the collagen fibres are more aligned and shorter as compared to the normal tissues. There is a clear association of the mean fibre length with the dogs survival times, the carcinomas presenting shorter collagen fibres indicate a worse survival rate.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/33707516/