Peer-reviewed veterinary case report
How tumor grade and blood vessel growth affect dog mammary cancer
By Diessler, M E et al.·Published in Veterinary and comparative oncology·2017·Departamento de Ciencias Bá·View original on PubMed →
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Original publication title: Canine mammary carcinomas: influence of histological grade, vascular invasion, proliferation, microvessel density and VEGFR2 expression on lymph node status and survival time.
- Species:
- dog
Plain-English summary
A study looked at 136 female dogs with mammary tumors to understand how different tumor characteristics affected their survival and lymph node involvement. The researchers found that factors like tumor grade and vascular invasion were important in predicting whether the cancer had spread to lymph nodes. Over 18 months, the dogs had a high chance of survival, with about 77% still alive at the end of the study. The findings suggest that dogs with certain tumor features may have a better chance of living longer, especially if their tumors show less vascular invasion.
People also search for: dog mammary tumor survival rate · canine mammary cancer treatment · what affects dog cancer survival · dog lymph node involvement cancer
Abstract
Spontaneous invasive non-inflammatory canine mammary carcinomas (CMC) and their regional lymph nodes (LN) were analysed (n = 136). Histological grade (HG) and vascular invasion (VI) in the tumours and lymph node status were recorded. Proliferation index (PI), microvessel density (MVD) and vascular endothelial growth factor receptor 2 (VEGFR2) expression were estimated using anti-proliferating cell nuclear antigen (PCNA), anti-von Willebrand factor and anti-Flk-1, respectively. Eighteen months follow-up was performed (34 bitches). Tumours of different grades showed differences regarding PI, Flk-1/integrated optical density (Flk-1/IOD) and MVD. Every feature showed significant association with LN status through bivariate analyses. From multivariate analyses, VI and Flk-1/IOD were selected to predict LN status. Data revealed that the probability of a CMC-bearing bitch to remain alive at 1, 4, 5 and 14-18 months was 0.91, 0.87, 0.81 and 0.77, respectively. Besides LN status, VI was the only feature positively correlated with survival time, although a trend to shorter survival of animal patients bearing high expressing VEGFR2 CMC was noted.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/26833549/