Peer-reviewed veterinary case report
Common gene changes in dog mammary tumors include MYC increase
By Kaja S Borge et al.·Published in PLoS ONE·2015·View original on DOAJ →
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Original publication title: Canine Mammary Tumours Are Affected by Frequent Copy Number Aberrations, including Amplification of MYC and Loss of PTEN.
- Species:
- dog
Plain-English summary
A study found that many dogs with mammary tumors had changes in their DNA that could affect how the cancer grows. Researchers looked at 117 tumors from 69 dogs and discovered that these genetic changes were linked to more aggressive forms of cancer. Specifically, they noted that the MYC gene was often amplified, while the PTEN gene was frequently lost. Understanding these genetic changes could help in developing better treatments for dogs with mammary tumors.
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Abstract
<h4>Background</h4>Copy number aberrations frequently occur during the development of many cancers. Such events affect dosage of involved genes and may cause further genomic instability and progression of cancer. In this survey, canine SNP microarrays were used to study 117 canine mammary tumours from 69 dogs.<h4>Results</h4>We found a high occurrence of copy number aberrations in canine mammary tumours, losses being more frequent than gains. Increased frequency of aberrations and loss of heterozygosity were positively correlated with increased malignancy in terms of histopathological diagnosis. One of the most highly recurrently amplified regions harbored the MYC gene. PTEN was located to a frequently lost region and also homozygously deleted in five tumours. Thus, deregulation of these genes due to copy number aberrations appears to be an important event in canine mammary tumour development. Other potential contributors to canine mammary tumour pathogenesis are COL9A3, INPP5A, CYP2E1 and RB1. The present study also shows that a more detailed analysis of chromosomal aberrations associated with histopathological parameters may aid in identifying specific genes associated with canine mammary tumour progression.<h4>Conclusions</h4>The high frequency of copy number aberrations is a prominent feature of canine mammary tumours as seen in other canine and human cancers. Our findings share several features with corresponding studies in human breast tumours and strengthen the dog as a suitable model organism for this disease.
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Search related cases →Original publication on DOAJ: https://doi.org/10.1371/journal.pone.0126371