Peer-reviewed veterinary case report
Carboxylate bioisosteres of pregabalin.
- Journal:
- Bioorganic & medicinal chemistry letters
- Year:
- 2006
- Authors:
- Schwarz, Jacob B et al.
- Affiliation:
- Pfizer Global Research and Development · United States
Abstract
Several beta-amino tetrazole analogs of gabapentin 1 and pregabalin 2 were prepared by one of two convergent, highly efficient routes, and their affinity for the alpha(2)-delta protein examined. Two select compounds with potent affinity for alpha(2)-delta, 8a and 16a, were subsequently tested in vivo in an audiogenic seizure model and found to elicit protective effects.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/16621528/