Peer-reviewed veterinary case report
Carboxylate bioisosteres of gabapentin.
- Journal:
- Bioorganic & medicinal chemistry letters
- Year:
- 2006
- Authors:
- Burgos-Lepley, Carmen E et al.
- Affiliation:
- Pfizer Global Research and Development · United States
Abstract
A series of carboxylate bioisosteres of structures related to gabapentin 1 have been prepared. When the carboxylate was replaced by a tetrazole, this group was recognized by the alpha2-delta protein. Further characterization of alpha2-delta binding compounds 14a and 14b revealed a similar pattern of functional in vitro and in vivo activity to gabapentin 1.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/15946842/